Publications

  1. Abraham, B. L.; Liyanage, W.; Nilsson, B. L. "Strategy to Identify Improved N-Terminal Modifications for Supramolecular Phenylalanine-Derived Hydrogelators," Langmuir 2019, 35, 14939-14948. DOI: 10.1021/acs.langmuir.9b02971
  2. Jagrosse, M. L.; Dean, D. A.; Rahman, A.; Nilsson, B. L. "RNAi therapeutic strategies for acuterespiratory distress syndrome," Translational Research 2019, 214, 30-49. DOI: 10.1016/j.trsl.2019.07.011
  3. Urban, J. M.; Ho, J.; Piester, G.; Fu, R.; Nilsson, B. L. "Rippled β-Sheet Formation by an Amyloid-β Fragment Indicates Expanded Scope of Sequence Space for Enantiomeric β-Sheet Peptide Coassembly," Molecules 2019, 24, N/A. DOI: 10.3390/molecules24101983
  4. Mahmoudinobar, F.; Urban, J. M.; Su, Z.; Nilsson, B. L.; Dias, C. L. "Thermodynamic Stability of Polar and Nonpolar Amyloid Fibrils," J. Chem. Theory Comput. 2019, 15, In Press. DOI: 10.1021/acs.jctc.9b00145
  5. Raymond, D. M.; Abraham, B. L.; Fujita, T.; Watrous, M. J.; Toriki, E. S.; Takano, T.; Nilsson, B. L. "Low-Molecular-Weight Supramolecular Hydrogels for Sustained and Localized in Vivo Drug Delivery," ACS Appl. Bio Mater. 2019, 2, 2116-2124. DOI: 10.1021/acsabm.9b00125
  6. Raymond, D. M.; Nilsson, B. L. "Multicomponent peptide assemblies," Chem. Soc. Rev. 2018, 47, 3659-3720. DOI: 10.1039/C8CS00115D
  7. Rajbhandary, A.; Brennessel, W. W.; Nilsson, B. L. "Comparison of the Self-Assembly Behavior of Fmoc-Phenylalanine and Corresponding Peptoid Derivatives," Cryst. Growth. Des. 2018, 18(2), 623-632. DOI: 10.1021/acs.cgd.7b00709
  8. Betush, R. J.; Urban, J.; Nilsson, B. L. "Balancing Hydrophobicity and Sequence Pattern to Influence Self-Assembly of Amphipathic Peptides," Biopolymers 2018, 110, e23099. DOI: 10.1002/bip.23099
  9. Liyanage, W.; Rubeo, P. W. "Redox-Sensitive Reversible Self-Assembly of Amino Acid-Naphthalene Diimide Conjugates," Interface Focus 2017, 7, 20160099. DOI: 10.1098/rsfs.2016.0099
  10. DiMaio, J. T. M.; Doran, T. M.; Ryan, D. M.; Raymond, D. M.; Nilsson, B. L. "Modulating Supramolecular Peptide Hydrogel Viscoelasticity Using Biomolecular Recognition," Biomacromolecules 2017, 18, 3591-3599. DOI: 10.1021/acs.biomac.7b00925
  11. DiMaio, J. T. M.; Raymond, D. M.; Nilsson, B. L. "Display of Functional Proteins on Supramolecular Peptide Nanofibrils Using a Split-Protein Strategy," Org. Biomol. Chem. 2017, 15, 5279-5283. DOI: 10.1039/C7OB01057E
  12. Rajbhandary, A.; Raymond, D. M.; Nilsson, B. L. "Self-Assembly, Hydrogelation, and Nanotube Formation by Cation-Modified Phenylalanine Derivatives," Langmuir 2017, 33, 5803-5813. DOI: 10.1021/acs.langmuir.7b00686
  13. Rajbhandary, A.; Nilsson, B. L. "Investigating the Effects of Peptoid Substitutions in Self-Assembly of Fmoc-Diphenylalanine Derivatives," Biopolymers 2017, 108, e22994. DOI: 10.1002/bip.22994
  14. Liyanage, W.; Cogan, N. M. B.; Nilsson, B. L. "Amyloid-Inspired Optical Waveguides from Multicomponent Crystalline Microtubes," ChemNanoMat 2016, 2, 800-804. DOI: 10.1002/cnma.201600123
  15. Welch, J. J.; Swanekamp, R. J.; King, C.; Dean, D. A.; Nilsson, B. L. "Functional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides," ACS Med. Chem. Lett. 2016, 7, 584-589. DOI: 10.1021/acsmedchemlett.6b00031
  16. Liyanage, W.; Nilsson, B. L. "Substituent Effects on the Self-Assembly/Coassembly and Hydrogelation of Phenylalanine Derivatives," Langmuir 2016, 32, 787–799. DOI: 10.1021/acs.langmuir.5b03227
  17. Pallo, S. P.; DiMaio, J.; Cook, A.; Nilsson, B.; Johnson, G. V. W. "Mechanisms of Tau and Aβ-induced Excitotoxicity," Brain Res. 2016, 1634, 119–131. DOI: 10.1016/j.brainres.2015.12.048
  18. Liyanage, W.; Brennessel, W. W.; Nilsson, B. L. "Spontaneous Transition of Self-Assembled Hydrogel Fibrils into Crystalline Microtubes Enables a Rational Strategy to Stabilize the Hydrogel State," Langmuir 2015, 31, 9933–9942. DOI: 10.1021/acs.langmuir.5b01953
  19. Liyanage, W.; Vats, K.; Rajbhandary, A.; Benoit, D. S. W.; Nilsson, B. L. "Multicomponent Dipeptide Hydrogels as Extracellular Matrix-Mimetic Scaffolds for Cell Culture Applications," Chem. Commun. 2015, 51, 11260–11263. DOI: 10.1039/C5CC03162A
  20. Swanekamp, R. J.; Welch, J. J.; Nilsson, B. L. "Proteolytic Stability of Amphipathic Peptide Hydrogels Composed of Self-Assembled Pleated β-Sheet or Coassembled Rippled β-Sheet Fibrils," Chem. Commun. 2014, 50, 10133–10136. DOI: 10.1039/C4CC04644G
  21. Cogan, N. M. B.; Bowerman, C. J.; Nogai, L. J.; Nilsson, B. L.; Krauss, T. D. "Selective Suspension of Single-Walled Carbon Nanotubes Using β-Sheet Polypeptides," J. Phys. Chem. C 2014, 118, In press. DOI: 10.1021/jp410870y
  22. Doran, T. M.; Ryan, D. M.; Nilsson, B. L. "Reversible Photocontrol of Self-Assembled Peptide Hydrogel Viscoelasticity," Polym. Chem. 2014, 5, 241–248. DOI: 10.1039/C3PY00903C
  23. Lee, N. R.; Bowerman, C. J.; Nilsson, B. L. "Sequence Length Determinants for Self-Assembly of Amphipathic β-Sheet Peptides," Biopolymers 2013, 100, 738–750. DOI: 10.1002/bip.22248
  24. Easterhoff, D.; DiMaio, J. T. M.; Liyanage, W.; Lo, C.-W.; Bae, W.; Doran, T. M.; Smrcka, A.; Nilsson, B. L.; Dewhurst, S. "Fluorescence Detection of Cationic Amyloid Fibrils in Human Semen," Bioorg. Med. Chem. Lett. 2013, 23, 5199–5202. DOI: 10.1016/j.bmcl.2013.06.097
  25. Lee, N. R.; Bowerman, C. J.; Nilsson, B. L. "Effects of Varied Sequence Pattern on the Self-Assembly of Amphipathic Peptides," Biomacromolecules 2013, 14, 3267–3277. DOI: 10.1021/bm400876s
  26. Bowerman, C. J.; Nilsson, B. L. "Self-Assembly of Amphipathic β-Sheet Peptides: Insights and Applications," Biopolymers 2012, 98, 169–184. DOI: 10.1002/bip.22058
  27. Swanekamp, R. J.; DiMaio, J. T. M.; Bowerman, C. J.; Nilsson, B. L. "Coassembly of Enantiomeric Amphipathic Peptides into Amyloid-Inspired Rippled β-Sheet Fibrils," J. Am. Chem. Soc. 2012, 134, 5556–5559. DOI: 10.1021/ja301642c
  28. Olsen, J. S.; DiMaio, J. T. M.; Doran, T. M.; Brown, C.; Nilsson, B. L.; Dewhurst, S. "Seminal Plasma Accelerates Semen-derived Enhancer of Viral Infection (SEVI) Fibril Formation by the Prostatic Acid Phosphatase (PAP[248–286]) Peptide," J. Biol. Chem. 2012, 287, 11842–11849. DOI: 10.1074/jbc.M111.314336
  29. Doran, T. M.; Anderson, E. A.; Latchney, S. E.; Opanashuk, L. A.; Nilsson, B. L. "Turn Nucleation Perturbs Amyloid-β Self-Assembly and Cytotoxicity," J. Mol. Biol. 2012, 421, 315–328. DOI: 10.1016/j.jmb.2012.01.055
  30. Doran, Todd M; Anderson, E. A.; Latchney, S. E.; Opanashuk, L. A.; Nilsson, B. L. "An Azobenzene Photoswitch Sheds Light on Turn Nucleation in Amyloid-β Self-Assembly ," ACS Chem. Neurosci. 2012, 3, 211–220. DOI: 10.1021/cn2001188
  31. Doran, Todd M.; Kamens, Alissa J.; Byrnes, Nadia K.; Nilsson, Bradley L. "Role of Amino Acid Hydrophobicity, Aromaticity and Molecular Volume on IAPP(20–29) Amyloid Self-Assembly," Proteins 2012, 80, 1053–1065. DOI: 10.1002/prot.24007
  32. Ryan, Derek M.; Nilsson, Bradley L. "Self-Assembled Amino Acids and Dipeptides as Noncovalent Hydrogels for Tissue Engineering," Polym. Chem. 2012, 3, 18–33. DOI: 10.1039/C1PY00335F
  33. Ryan, Derek M.; Doran, Todd M.; Nilsson, Bradley L. "Complementary π-π Interactions Induce Multi-Component Coassembly into Functional Fibrils," Langmuir 2011, 27, 11145–11156. DOI: 10.1021/la202070d
  34. Bowerman, Charles J.; Liyanage, Wathsala, Federation, Alexander J.; Nilsson, Bradley L. "Tuning β-Sheet Peptide Self-Assembly and Hydrogelation Behavior by Modification of Sequence Hydrophobicity and Aromaticity," Biomacromolecules 2011, 12, 2735–2745. DOI: 10.1021/bm200510k
  35. Ryan, Derek M.; Doran, Todd M.; Anderson, Samuel B.; Nilsson, Bradley L. "Effect of C-Terminal Modification on the Self-Assembly and Hydrogelation of Fluorinated Fmoc-Phe," Langmuir 2011, 27, 4029–4039. DOI: 10.1021/la1048375
  36. Easterhoff, David; DiMaio, John T. M.; Doran, Todd M.; Dewhurst, Stephen; Nilsson, Bradley L. "Enhancement of HIV-1 Infectivity by Simple, Self-Assembling Modular Peptides," Biophys. J. 2011, 100, 1325–1334. DOI: 10.1016/j.bpj.2011.01.037
  37. Senguen, F. Timur; Doran, Todd M.; Anderson, Elizabeth A.; Nilsson, Bradley L. "Clarifying the Influence of Core Amino Acid Hydrophobicity, Secondary Structure Propensity, and Molecular Volume on Amyloid-β 16–22 Self-Assembly," Mol. BioSyst. 2011, 7, 497–510. DOI: 10.1039/C0MB00210K
  38. Senguen, F. Timur; Lee, Naomi, R.; Gu, Xianfeng; Ryan, Derek M.; Doran, Todd M.; Anderson, Elizabeth A.; Nilsson, Bradley L. "Probing Aromatic, Hydrophobic, and Steric Effects on the Self-Assembly of an Amyloid-β Fragment Peptide," Mol. BioSyst. 2011, 7, 486–496. DOI: 10.1039/C0MB00080A
  39. Ryan, Derek M.; Doran, Todd M.; Nilsson, Bradley L. "Stabilizing Self-Assembled Fmoc-F5-Phe Hydrogels by Co-Assembly with PEG-Functionalized Monomers," Chem. Commun. 2011, 47, 475–477. DOI: 10.1039/C0CC02217A
  40. Olsen, Joanna S.; Brown, Caitlin; Capule, Christina C.; Rubinshtein, Mark; Doran, Todd M.; Srivastava, Rajesh K.; Feng, Chanyong; Nilsson, Bradley L.; Yang, Jerry; Dewhurst, Stephen "Amyloid Binding Small Molecules Efficiently Block SEVI and Semen-Mediated Enhancement of HIV-1 Infection," J. Biol. Chem. 2010, 285, 35488–35496. DOI: 10.1074/jbc.M110.163659
  41. Ryan, Derek M.; Anderson, Samuel B.; Nilsson, Bradley L. "The Influence of Side-Chain Halogenation on the Self-Assembly and Hydrogelation of Fmoc-Phenylalanine Derivatives," Soft Matter 2010, 6, 3220–3231. DOI: 10.1039/c0sm00018c
  42. Bowerman, Charles, J.; Nilsson, Bradley L. "A Reductive Trigger for Peptide Self-Assembly and Hydrogelation," J. Am. Chem. Soc. 2010, 132, 9526–9527. DOI: 10.1021/ja1025535
  43. Ryan, Derek M.; Anderson, Samuel B.; Senguen, F. Timur; Youngman, Randall E.; Nilsson, Bradley L. "Self-Assembly and Hydrogelation Promoted by F5-Phenylalanine," Soft Matter 2010, 6, 475–479. DOI: 10.1039/b916738b
  44. Bowerman, Charles J.; Ryan, Derek M.; Nissan, David A.; Nilsson, Bradley L. "The Effect of Increasing Hydrophobicity on the Self-Assembly of Amphipathic β-Sheet Peptides," Mol. BioSyst. 2009, 5, 1058–1069. DOI: 10.1039/b904439f