The Tour of Collective Wisdom presents:
May Require Mojo


Literature procedures do not always give consistent results. Sometimes this is the fault of the chemist, and sometimes the fault of the chemistry. This list contains reaction chemistry from the literature that is capricious or difficult to reproduce. This page is a pure reflection of visitor input - it has never been edited internally (disclaimer: the opinions displayed here are not those of the site administrator).

Procedure:
Reference:
Verification:
Procedure Reference This procedure requires mojo Number of responses Percent who agree
DIBAl-H reduction of simple methyl esters to aldehydes J. Am. Chem. Soc.; 1990; 112(17) pp agree disagree 9 77%
Iodination of alcohol with CeCl3.7H2O/NaI System J.Org.Chem. 2000, 65, 2830-2833 agree disagree 13 69%
Benzylic Oxidation with IBX JACS 124 (10), 2245-2258 (2002) agree disagree 63 66%
DIBAl-H reduction of simple methyl esters to aldehydes Organic Syntheses agree disagree 344 56%
Roush's asymmetric crotylation J. Am. Chem. Soc.; 1990; 112(17) pp 6339 - 6348; http://dx.doi.org/10.1021/ja00173a023 agree disagree 32 53%
shapiron reaction Org react. 1976,23,405 agree disagree 4 50%
Bellamy reduction JACS 89, 1994 agree disagree 11 45%
[Pd(nbd)(Ma)] K.Itoh, Chem. Lett, 1977, 877-880 agree disagree 19 42%
Schwartz's Reagent Organic Syntheses agree disagree 75 41%
Activation of allylbarium Organic Syntheses agree disagree 82 40%
Shapiro Reaction Org React. 1976, 23, 405 agree disagree 51 39%
Dess Martin Periodinane J. Org. Chem. 1983, 48, 4155. or J.Org.Chem., 64 (1999) 4537. agree disagree 46 39%
Acetonide of tartaric acid Van Deusen et al. Org Syn, Ann. Vol. 68, p.92; Coll. Vol. 8, p.155 agree disagree 58 25%
Cross-metathesis of terminal olefins Grubbs agree disagree 136 25%
Evans Auxiliary Aldol Condensation Organic Syntheses agree disagree 337 5%