The Tour of Collective Wisdom presents:
May Require Mojo


Literature procedures do not always give consistent results. Sometimes this is the fault of the chemist, and sometimes the fault of the chemistry. This list contains reaction chemistry from the literature that is capricious or difficult to reproduce. This page is a pure reflection of visitor input - it has never been edited internally (disclaimer: the opinions displayed here are not those of the site administrator).

Procedure:
Reference:
Verification:
Procedure Reference This procedure requires mojo Number of responses Percent who agree
Organocatalysed direct arylation C. Sun, H. Li, D. Yu, M. Yu, X. Zhou, X. Lu, K. Huang, S. Zheng, B. Li, Z. Shi: Nature Chem. 2010, 2, 1044-1049 agree disagree 126 98%
Preparation of organo selenides Singh, D.; Alberto, E. E.; Rodrigues, O. E. D.; Braga, A. L. Green Chem. 2009, 11, 1521-1524. agree disagree 119 96%
Reduction of nitrile to aldehyde with 2.3 equiv. of DIBAL-H Chem. Eur. J., 2002, 8(9), 2000-2004 agree disagree 94 84%
DIBAl-H reduction of simple methyl esters to aldehydes J. Am. Chem. Soc.; 1990; 112(17) pp agree disagree 84 78%
Benzylic Oxidation with IBX JACS 124 (10), 2245-2258 (2002) agree disagree 115 69%
Iodination of alcohol with CeCl3·7H2O/NaI System J.Org.Chem. 2000, 65, 2830-2833 agree disagree 32 68%
Roush's asymmetric crotylation J. Am. Chem. Soc.; 1990; 112(17) pp 6339 - 6348; http://dx.doi.org/10.1021/ja00173a023 agree disagree 47 63%
Novel system for decarboxylative bromination of a,b-unsaturated carboxylic acids with diacetoxyiodobenzene Chem. Pharm. Bull. 57(11), 1243-1245 (2009) agree disagree 11 63%
DIBAl-H reduction of simple methyl esters to aldehydes Organic Syntheses agree disagree 422 59%
Schwartz's Reagent Organic Syntheses agree disagree 101 44%
[Pd(nbd)(Ma)] K.Itoh, Chem. Lett, 1977, 877-880 agree disagree 27 44%
Activation of allylbarium Organic Syntheses agree disagree 91 43%
Shapiro Reaction Org React. 1976, 23, 405 agree disagree 68 41%
Bellamy reduction JACS 89, 1994 agree disagree 27 37%
Shi Epoxidation JACS 1997, 119 (46), 11224-11235 agree disagree 30 36%
Dess Martin Periodinane J. Org. Chem. 1983, 48, 4155. or J.Org.Chem., 64 (1999) 4537. agree disagree 124 34%
Acetonide of tartaric acid Van Deusen et al. Org Syn, Ann. Vol. 68, p.92; Coll. Vol. 8, p.155 agree disagree 82 23%
Cross-metathesis of terminal olefins Grubbs agree disagree 200 21%
Evans Auxiliary Aldol Condensation Organic Syntheses agree disagree 403 6%
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