The Tour of Collective Wisdom presents:
May Require Mojo


Literature procedures do not always give consistent results. Sometimes this is the fault of the chemist, and sometimes the fault of the chemistry. This list contains reaction chemistry from the literature that is capricious or difficult to reproduce. This page is a pure reflection of visitor input - it has never been edited internally (disclaimer: the opinions displayed here are not those of the site administrator).

Procedure:
Reference:
Verification:
Procedure Reference This procedure requires mojo Number of responses Percent who agree
Organocatalysed direct arylation C. Sun, H. Li, D. Yu, M. Yu, X. Zhou, X. Lu, K. Huang, S. Zheng, B. Li, Z. Shi: Nature Chem. 2010, 2, 1044-1049 agree disagree 107 99%
Preparation of organo selenides Singh, D.; Alberto, E. E.; Rodrigues, O. E. D.; Braga, A. L. Green Chem. 2009, 11, 1521-1524. agree disagree 107 98%
Reduction of nitrile to aldehyde with 2.3 equiv. of DIBAL-H Chem. Eur. J., 2002, 8(9), 2000-2004 agree disagree 73 91%
DIBAl-H reduction of simple methyl esters to aldehydes J. Am. Chem. Soc.; 1990; 112(17) pp agree disagree 51 84%
Benzylic Oxidation with IBX JACS 124 (10), 2245-2258 (2002) agree disagree 76 69%
Iodination of alcohol with CeCl3·7H2O/NaI System J.Org.Chem. 2000, 65, 2830-2833 agree disagree 25 64%
Roush's asymmetric crotylation J. Am. Chem. Soc.; 1990; 112(17) pp 6339 - 6348; http://dx.doi.org/10.1021/ja00173a023 agree disagree 38 60%
DIBAl-H reduction of simple methyl esters to aldehydes Organic Syntheses agree disagree 380 58%
Novel system for decarboxylative bromination of a,b-unsaturated carboxylic acids with diacetoxyiodobenzene Chem. Pharm. Bull. 57(11), 1243-1245 (2009) agree disagree 2 50%
Bellamy reduction JACS 89, 1994 agree disagree 16 50%
Schwartz's Reagent Organic Syntheses agree disagree 88 46%
[Pd(nbd)(Ma)] K.Itoh, Chem. Lett, 1977, 877-880 agree disagree 23 43%
Activation of allylbarium Organic Syntheses agree disagree 88 43%
Dess Martin Periodinane J. Org. Chem. 1983, 48, 4155. or J.Org.Chem., 64 (1999) 4537. agree disagree 81 41%
Shapiro Reaction Org React. 1976, 23, 405 agree disagree 59 38%
Cross-metathesis of terminal olefins Grubbs agree disagree 155 25%
Acetonide of tartaric acid Van Deusen et al. Org Syn, Ann. Vol. 68, p.92; Coll. Vol. 8, p.155 agree disagree 72 25%
Shi Epoxidation JACS 1997, 119 (46), 11224-11235 agree disagree 17 23%
Evans Auxiliary Aldol Condensation Organic Syntheses agree disagree 371 6%