The Tour of Collective Wisdom presents:
Should you buy it from a commercial supplier, or make it yourself?


Some reagents offered by chemical suppliers can be prepared easily in the lab, sometimes in higher quality, or at much lower cost. Other reagents are difficult or time-consuming to prepare, and time and effort are saved if these are purchased from a supplier instead. There is some difference on opinion on which reagents fall into these categories, as reflected in the table.

Reagent:
Reference for making this reagent (optional):
This reagent should be made in the lab.
This reagent should be bought from a supplier.
Verification:

Reagent Reference Should this reagent be... Number of responses
(+) or (–)-(Ipc)2BOMe for Brown allylations/crotylations Jadhay, Prabhakar K.; Bhat, Krishna S.; Perumal, P. Thirumalai; Brown, Herbert C. Journal of Organic Chemistry, 1986, 51(4), 432-439. made
bought
89 61% say make it
1,8-diaminonaphthalene made
bought
25 92% say buy it
1-acetoxybutadiene made
bought
13 84% say buy it
LDA
LiN(iPr)2
De Nicola, Antoinette; Einhorn, Jacques; Luche, Jean Louis. Journal of Chemical Research, Synopses, 1991, 10,278. made
bought
636 94% say make it
N-Benzylhydroxylamine hydrochloride Coskun, N.; Parlar, A. Synthetic Communications, 2005, 35(18), 2445-2451 made
bought
43 90% say buy it
4,4,5,5-tetramethyl-1,3,2-dioxaborolane made
bought
2 100% say buy it
5,7-Dihydroxy-2-phenyl-4H-chromen-4-one(chrysin) made
bought
2 100% say buy it
AD mix made
bought
2 100% say buy it
AD mix alpha and beta Sharpless, K. B.; Amberg, W.; Bennani, Y. L.; Crispino, G. A.; Hartung, J.; Jeong, K.-S.; Kwong, H.-L.; Morikawa, K.; Wang, Z.-M.; Xu, D.; Zhang, X.-L. J. Org. Chem. 1992, 57, 2768. made
bought
262 87% say buy it
AIBN made
bought
69 95% say buy it
AgNO3 made
bought
146 93% say buy it
Alkyne Hydration Catalyst Grotjahn, D.B and Lev D. J. Am. Chem. Soc. 2004, 126, 12232 made
bought
59 96% say buy it
BOM-Cl (benzyloxymethyl chloride) Connor, D: S.; Klein, G.W.; Taylor, G. N. Org. Synth. Coll. Vol. VI, 101-103. made
bought
120 84% say buy it
Boc-pyrrole Slaman, H., Abraham, Y., Tal, S., Meltzman, S., Kapon, M., Tessler, N., Speiser, S., and Eichen, Y. Eur. J. Org. Chem. 2005, 2207-2212. made
bought
17 88% say buy it
Boronic acids Hall, Dennis G.,ed. Boronic Acids. WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2005. ISBN 3-527-30991-8 made
bought
104 74% say buy it
Comins Reagent

Comins DL, Dehghani A. Tetrahedron Letters 33 (42): 6299-6302 Oct 13 1992. made
bought
150 86% say buy it
Copper(I)bromide - dimethylsulfide complex House, H. O.;Chu, C.-Y.;Wilkins, J. M.; Umen, M. J., J. Org. Chem. 1075, 40, 1460. made
bought
39 64% say make it
DABSO Bao Nguyen, Edward J. Emmett, and Michael C. Willis J. AM. CHEM. SOC. 2010, 132, 16372%9616373 made
bought
1 100% say make it
DMT-MM.Cl or .BF4 Tetrahedron Letters 40 (1999) 5327-5330 made
bought
1 100% say make it
Danishefsky's Diene

Danishefsky, S. et al, J.A.C.S, 1974, 96, 7807; 1978, 100, 6536. made
bought
169 72% say make it
Dess-Martin Periodinane

Dess, DB; Martin, J.C. J. Am. Chem. Soc. 1991 113, 7277-7287; Boeckman, Jr. Robert K.; Shao, Pengchen; Mullins, Joseph J. Organic Syntheses, Vol. 77, 141. made
bought
391 76% say make it
Dibutylboron Triflate Evans procedure; JACS 1981 103 3099 made
bought
68 72% say make it
Grignard Reagents Methylmagnesium Bromide
Herman G. Richey Jr., The Pennsylvania State University
Encyclopedia of Reagents for Organic Synthesis
Copyright 2001 John Wiley & Sons, Ltd
DOI: 10.1002/047084289X.rm206
made
bought
430 74% say make it
Grubbs' Catalyst made
bought
13 92% say buy it
HClO4 SiO2 made
bought
18 88% say make it
Hydroquinone Bianchi, D.; D'Aloisio, R.; Bortolo, R.; Ricci, M. Applied Catalysis, A: General, 2007, 327(2), 295-299 made
bought
60 90% say buy it
IBX Alex G. Fallis, University of Ottawa
Pierre E. Tessier, University of Ottawa
Encyclopedia of Reagents for Organic Synthesis
Copyright 2003 John Wiley & Sons, Ltd
DOI: 10.1002/047084289X.rn0021
Article Onlie Posting Date:April 15, 2003
made
bought
243 93% say make it
Imidazole 1-sulfonyl azide (salts) Org. Lett., 2007, 9 (19), pp 3797%963800 made
bought
1 100% say make it
Iminoiodinanes made
bought
7 71% say buy it
Iodobenzene diacetate Synthesis 2005, 1932 made
bought
32 90% say buy it
LHMDS

Rathke, M.W. OSC 1988, 6, 598. made
bought
366 70% say buy it
LiOtBu Chisholm, Malcom H.; Drake, Simon R.; Naiini, Ahmad A.; Streib, William E. Polyhedron, 1991, 10(8), 805-810. made
bought
90 82% say buy it
Lindlar catalyst Helv. Chim. Acta, 1952, 35, 446-50 made
bought
154 95% say buy it
Lithium tetramethylpiperidine Mike Campbell, University of Waterloo (Original Commentary)
Victor Snieckus, University of Waterloo (Orignal Commentary)
Ellen W. Baxter, Johnson & Johnson Pharmaceutical Research and Development, LLC
Encyclopledia of Reagents for Organic Synthesis
Copyright 2008 John Wiley & Sons, Ltd
DOI: 10.1002/047084289X.r1143.pub2
Article Online Posting Date: March 14, 2008
made
bought
60 93% say make it
MOM-Cl Amato, J.S.; Karady, S.; Sletzinger, M.; Weinstock, L.M. Synthesis, 1979, 12, 970-971. made
bought
215 80% say buy it
Meldrum's acid made
bought
50 88% say buy it
Pd2(dba)3 Ukai, T; Kawazura, H.; Ishii, Y.; Bonnet, J. J.; Ibers, J. A. J. Organomet. Chem. 1974, 65, 253-266. made
bought
440 79% say buy it
Potassium t-butoxide Johnson, W.S.; Schneider, W.P. Org. Synth. Coll. Vol. 1963, 4, 132.
Link
made
bought
239 96% say buy it
Pyridine Tetrahydroborato Zinc Zeynizadeh, B.; Faraji, F. Bull. Korean Chem. Soc., 2003, 24(4). made
bought
16 56% say make it
Pyridinium Chlorochromate Corey, E.J. and Suggs, W., Tetrahedron Letters, 31, p. 2647-2650, 1975 made
bought
243 86% say buy it
Raney Nickel Tietze, L.-F.; Eicher, T. Reactions and Syntheses in the Organic Chemistry Lab 1989, 71-72, University Science Books made
bought
143 84% say buy it
Schwartz Reagent made
bought
32 78% say buy it
Shi Catalyst Tu, Y.; Frohn, M.; Wang, Z.-X.; Shi Y. Org. Synth. 2003, 80, 1. made
bought
22 77% say make it
SmI2 Girard, P.; Namy, J.L.; Kagan, H.B. JACS 1980, 102, 2693. made
bought
225 72% say make it
Sodium Tetrakis[(3,5-trifluoromethyl)phenyl]borate (Na BARF) Yakelis and Bergman, Organometallics 24, 3579-3581 (2005) made
bought
19 84% say make it
Sodium methoxide/ethoxide Chandran, K.; Nithya, R.; Sankaran, K.; Goplan, A.; Ganesan, V. Bull. Mater. Sci., 2006, 29(2), 173-179. made
bought
308 69% say make it
Stryker's Reagent Lee, D.; Yun, J. Tetrahedron Letters, 2005, 46(12), 2037-2039. made
bought
28 64% say make it
TBSOTf Tetrahedron Lett. 1981, 22,3455-3458 made
bought
34 82% say buy it
TEA Khedkar, V.; Tillack, A.; Benisch, C.; Melder, J.; Beller, M. Journal of Molecular Catalysis A: Chemical, 2005, 241(1-2), 175-183. made
bought
167 97% say buy it
TMS diazomethane Organic Syntheses Collected Volume, Volume 8, page 612 made
bought
74 91% say buy it
TMSOTf Goundry, W.R.F. Syn. Lett., 2003, 12, 1940-1941. made
bought
193 90% say buy it
TPAP

J. Chem. Soc. Chem. Commun. 1987, 1625-1627 made
bought
209 90% say buy it
Tetrakistriphenylphosphine palladium
Pd(PPh3)4
Coulson, D. Inorg. Synth 1972, 13, 121. made
bought
384 60% say buy it
Wilkinson's Catalyst
Rh(PPh3)3Cl
J.A. Osborn, F.H. Jardine, G. Wilkinson and J.F. Young. J. Chem. Soc., A (1966) p. 1711. made
bought
204 85% say buy it
Wittig Reagents Corbridge, D.E.C. Phosphorus: An Outline of its Chemistry, Biochemistry, and Technology. Amsterdam: Elsevier 5th ed. ISBN 0-444-89307-5 made
bought
274 84% say make it
all analogs of the CBS (oxazaborolidines) reagent Mathre, D.J.; Shinkai, I.; Zaidlewicz, M.; Krzemi, M. Encyclopedia of Reagents for Organic Synthesis, Copyright 2007 John Wiley & Sons, Ltd.
Link
made
bought
113 71% say make it
allylmagnesium bromide made
bought
208 71% say buy it
amalgam made
bought
7 57% say make it
anhydrous HCl made
bought
138 75% say make it
beaucage reagent Marchan, V.; Gilbert, M.; Messeguer, A.; Pedroso, E.; Grandas, A. Synthesis, 1999, 1, 43-45. made
bought
18 88% say buy it
dess-martin periodinane made
bought
49 75% say make it
hydrochloric acid made
bought
34 88% say buy it
methyl CBS (oxazaborolidine) Organic Syntheses, Coll. Vol. 9, p.676; Vol. 74, p.50 made
bought
104 66% say buy it
phenylacetylene made
bought
37 83% say buy it
tributyltinhydride made by reduction of Bu3SnCl with NaBH4 made
bought
183 90% say buy it
vinylmagnesium bromide made
bought
169 74% say buy it
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