The Tour of Collective Wisdom presents:
Should you buy it from a commercial supplier, or make it yourself?


Some reagents offered by chemical suppliers can be prepared easily in the lab, sometimes in higher quality, or at much lower cost. Other reagents are difficult or time-consuming to prepare, and time and effort are saved if these are purchased from a supplier instead. There is some difference on opinion on which reagents fall into these categories, as reflected in the table.

Reagent:
Reference for making this reagent (optional):
This reagent should be made in the lab.
This reagent should be bought from a supplier.
Verification:

Reagent Reference Should this reagent be... Number of responses
(+) or (–)-(Ipc)2BOMe for Brown allylations/crotylations Jadhay, Prabhakar K.; Bhat, Krishna S.; Perumal, P. Thirumalai; Brown, Herbert C. Journal of Organic Chemistry, 1986, 51(4), 432-439. made
bought
90 62% say make it
1,8-diaminonaphthalene made
bought
26 92% say buy it
1-acetoxybutadiene made
bought
14 85% say buy it
LDA
LiN(iPr)2
De Nicola, Antoinette; Einhorn, Jacques; Luche, Jean Louis. Journal of Chemical Research, Synopses, 1991, 10,278. made
bought
644 94% say make it
N-Benzylhydroxylamine hydrochloride Coskun, N.; Parlar, A. Synthetic Communications, 2005, 35(18), 2445-2451 made
bought
44 90% say buy it
4,4,5,5-tetramethyl-1,3,2-dioxaborolane made
bought
3 100% say buy it
5,7-Dihydroxy-2-phenyl-4H-chromen-4-one(chrysin) made
bought
3 100% say buy it
AD mix made
bought
4 100% say buy it
AD mix alpha and beta Sharpless, K. B.; Amberg, W.; Bennani, Y. L.; Crispino, G. A.; Hartung, J.; Jeong, K.-S.; Kwong, H.-L.; Morikawa, K.; Wang, Z.-M.; Xu, D.; Zhang, X.-L. J. Org. Chem. 1992, 57, 2768. made
bought
264 87% say buy it
AIBN made
bought
72 94% say buy it
AgNO3 made
bought
152 93% say buy it
Alkyne Hydration Catalyst Grotjahn, D.B and Lev D. J. Am. Chem. Soc. 2004, 126, 12232 made
bought
60 96% say buy it
BOM-Cl (benzyloxymethyl chloride) Connor, D: S.; Klein, G.W.; Taylor, G. N. Org. Synth. Coll. Vol. VI, 101-103. made
bought
121 84% say buy it
Boc-pyrrole Slaman, H., Abraham, Y., Tal, S., Meltzman, S., Kapon, M., Tessler, N., Speiser, S., and Eichen, Y. Eur. J. Org. Chem. 2005, 2207-2212. made
bought
18 83% say buy it
Boronic acids Hall, Dennis G.,ed. Boronic Acids. WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2005. ISBN 3-527-30991-8 made
bought
105 74% say buy it
Comins Reagent

Comins DL, Dehghani A. Tetrahedron Letters 33 (42): 6299-6302 Oct 13 1992. made
bought
152 86% say buy it
Copper(I)bromide - dimethylsulfide complex House, H. O.;Chu, C.-Y.;Wilkins, J. M.; Umen, M. J., J. Org. Chem. 1075, 40, 1460. made
bought
42 59% say make it
DABSO Bao Nguyen, Edward J. Emmett, and Michael C. Willis J. AM. CHEM. SOC. 2010, 132, 16372%9616373 made
bought
2 100% say make it
DMT-MM.Cl or .BF4 Tetrahedron Letters 40 (1999) 5327-5330 made
bought
2 100% say make it
Danishefsky's Diene

Danishefsky, S. et al, J.A.C.S, 1974, 96, 7807; 1978, 100, 6536. made
bought
170 72% say make it
Dess-Martin Periodinane

Dess, DB; Martin, J.C. J. Am. Chem. Soc. 1991 113, 7277-7287; Boeckman, Jr. Robert K.; Shao, Pengchen; Mullins, Joseph J. Organic Syntheses, Vol. 77, 141. made
bought
403 76% say make it
Dibutylboron Triflate Evans procedure; JACS 1981 103 3099 made
bought
69 72% say make it
Fremy's salt W. Moser and R.A. Howie, J. Chem. Soc. A, 3039 (1968) made
bought
2 100% say make it
Grignard Reagents Methylmagnesium Bromide
Herman G. Richey Jr., The Pennsylvania State University
Encyclopedia of Reagents for Organic Synthesis
Copyright 2001 John Wiley & Sons, Ltd
DOI: 10.1002/047084289X.rm206
made
bought
437 75% say make it
Grubbs' Catalyst made
bought
17 94% say buy it
HClO4 SiO2 made
bought
19 89% say make it
Hydroquinone Bianchi, D.; D'Aloisio, R.; Bortolo, R.; Ricci, M. Applied Catalysis, A: General, 2007, 327(2), 295-299 made
bought
61 90% say buy it
IBX Alex G. Fallis, University of Ottawa
Pierre E. Tessier, University of Ottawa
Encyclopedia of Reagents for Organic Synthesis
Copyright 2003 John Wiley & Sons, Ltd
DOI: 10.1002/047084289X.rn0021
Article Onlie Posting Date:April 15, 2003
made
bought
247 93% say make it
Imidazole 1-sulfonyl azide (salts) Org. Lett., 2007, 9 (19), pp 3797%963800 made
bought
2 100% say make it
Iminoiodinanes made
bought
8 75% say buy it
Iodobenzene diacetate Synthesis 2005, 1932 made
bought
33 90% say buy it
LHMDS

Rathke, M.W. OSC 1988, 6, 598. made
bought
369 70% say buy it
LiOtBu Chisholm, Malcom H.; Drake, Simon R.; Naiini, Ahmad A.; Streib, William E. Polyhedron, 1991, 10(8), 805-810. made
bought
92 81% say buy it
Lindlar catalyst Helv. Chim. Acta, 1952, 35, 446-50 made
bought
159 95% say buy it
Lithium tetramethylpiperidine Mike Campbell, University of Waterloo (Original Commentary)
Victor Snieckus, University of Waterloo (Orignal Commentary)
Ellen W. Baxter, Johnson & Johnson Pharmaceutical Research and Development, LLC
Encyclopledia of Reagents for Organic Synthesis
Copyright 2008 John Wiley & Sons, Ltd
DOI: 10.1002/047084289X.r1143.pub2
Article Online Posting Date: March 14, 2008
made
bought
62 93% say make it
MOM-Cl Amato, J.S.; Karady, S.; Sletzinger, M.; Weinstock, L.M. Synthesis, 1979, 12, 970-971. made
bought
217 79% say buy it
Meldrum's acid made
bought
52 88% say buy it
Pd2(dba)3 Ukai, T; Kawazura, H.; Ishii, Y.; Bonnet, J. J.; Ibers, J. A. J. Organomet. Chem. 1974, 65, 253-266. made
bought
444 78% say buy it
Potassium t-butoxide Johnson, W.S.; Schneider, W.P. Org. Synth. Coll. Vol. 1963, 4, 132.
Link
made
bought
241 96% say buy it
Pyridine Tetrahydroborato Zinc Zeynizadeh, B.; Faraji, F. Bull. Korean Chem. Soc., 2003, 24(4). made
bought
17 58% say make it
Pyridinium Chlorochromate Corey, E.J. and Suggs, W., Tetrahedron Letters, 31, p. 2647-2650, 1975 made
bought
246 86% say buy it
Raney Nickel Tietze, L.-F.; Eicher, T. Reactions and Syntheses in the Organic Chemistry Lab 1989, 71-72, University Science Books made
bought
145 84% say buy it
Schwartz Reagent made
bought
33 78% say buy it
Shi Catalyst Tu, Y.; Frohn, M.; Wang, Z.-X.; Shi Y. Org. Synth. 2003, 80, 1. made
bought
23 78% say make it
SmI2 Girard, P.; Namy, J.L.; Kagan, H.B. JACS 1980, 102, 2693. made
bought
227 72% say make it
Sodium Tetrakis[(3,5-trifluoromethyl)phenyl]borate (Na BARF) Yakelis and Bergman, Organometallics 24, 3579-3581 (2005) made
bought
21 80% say make it
Sodium methoxide/ethoxide Chandran, K.; Nithya, R.; Sankaran, K.; Goplan, A.; Ganesan, V. Bull. Mater. Sci., 2006, 29(2), 173-179. made
bought
314 70% say make it
Stryker's Reagent Lee, D.; Yun, J. Tetrahedron Letters, 2005, 46(12), 2037-2039. made
bought
29 65% say make it
TBSOTf Tetrahedron Lett. 1981, 22,3455-3458 made
bought
37 83% say buy it
TEA Khedkar, V.; Tillack, A.; Benisch, C.; Melder, J.; Beller, M. Journal of Molecular Catalysis A: Chemical, 2005, 241(1-2), 175-183. made
bought
170 97% say buy it
TMS diazomethane Organic Syntheses Collected Volume, Volume 8, page 612 made
bought
76 92% say buy it
TMSOTf Goundry, W.R.F. Syn. Lett., 2003, 12, 1940-1941. made
bought
193 90% say buy it
TPAP

J. Chem. Soc. Chem. Commun. 1987, 1625-1627 made
bought
210 90% say buy it
Tetrakistriphenylphosphine palladium
Pd(PPh3)4
Coulson, D. Inorg. Synth 1972, 13, 121. made
bought
390 61% say buy it
Wilkinson's Catalyst
Rh(PPh3)3Cl
J.A. Osborn, F.H. Jardine, G. Wilkinson and J.F. Young. J. Chem. Soc., A (1966) p. 1711. made
bought
205 85% say buy it
Wittig Reagents Corbridge, D.E.C. Phosphorus: An Outline of its Chemistry, Biochemistry, and Technology. Amsterdam: Elsevier 5th ed. ISBN 0-444-89307-5 made
bought
277 84% say make it
all analogs of the CBS (oxazaborolidines) reagent Mathre, D.J.; Shinkai, I.; Zaidlewicz, M.; Krzemi, M. Encyclopedia of Reagents for Organic Synthesis, Copyright 2007 John Wiley & Sons, Ltd.
Link
made
bought
114 71% say make it
allylmagnesium bromide made
bought
213 70% say buy it
amalgam made
bought
8 62% say make it
anhydrous HCl made
bought
144 75% say make it
beaucage reagent Marchan, V.; Gilbert, M.; Messeguer, A.; Pedroso, E.; Grandas, A. Synthesis, 1999, 1, 43-45. made
bought
19 89% say buy it
dess-martin periodinane made
bought
50 76% say make it
hydrochloric acid made
bought
38 89% say buy it
methyl CBS (oxazaborolidine) Organic Syntheses, Coll. Vol. 9, p.676; Vol. 74, p.50 made
bought
107 66% say buy it
phenylacetylene made
bought
39 84% say buy it
tributyltinhydride made by reduction of Bu3SnCl with NaBH4 made
bought
186 90% say buy it
vinylmagnesium bromide made
bought
173 75% say buy it
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